Liposomes/vesicle diameter by mass photometry
Hi! I was wondering if you are aware of any cases of mass photometry being used to quantify the size of small unilamellar vesicles? I'm considering using MP as an alternative to something like dynamic light scattering to do this. Thanks for any advice here!
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Hi Katrina,
One of mass photometry's greatest advantages is that it measures the mass of biomolecules and complexes without having a bias for the size, diameter or hydrodynamic radius. The measurement relies only on the mass of the particle, making measurements of particles with different shapes or sizes comparable, within the working range 30 kDa – 6 MDa, and for particles smaller than roughly 40 nm.
Hope this helps!