So a large 300nm diameter spherical particle would be too large.
But the main thing to really consider is the molecular mass is within our specification - 30kDa to 5MDa.
However, we have seen nice data from long (200-300nm), but very thin biomolecules like collagen monomers, hyaluronic acid, myosin microfilaments, long un-coiled DNA etc.
Hi Matthew, the short answer is … it depends.
So a large 300nm diameter spherical particle would be too large.
But the main thing to really consider is the molecular mass is within our specification - 30kDa to 5MDa.
However, we have seen nice data from long (200-300nm), but very thin biomolecules like collagen monomers, hyaluronic acid, myosin microfilaments, long un-coiled DNA etc.
Hope that answers your question!